Article

Homology mediated end joining enables efficient non-viral targeted integration of large DNA templates in primary human T cells

2021-11-13

Abstract excerpt

Adoptive cellular therapy using genetically engineered immune cells holds tremendous promise for the treatment of advanced cancers. While the number of available receptors targeting tumor specific antigens continues to grow, the current reliance on viral vectors for clinical production of engineered immune cells remains a significant bottleneck limiting translation of promising new therapies. Here, we describe an...

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Literature Corpus work: 749990c7-0d29-534b-aa01-8d6686dccefe
DOI: 10.1101/2021.11.12.468427

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