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Article

Dissecting the interactions of the ISG15-USP18-STAT2 inhibitory complex

2026-03-27

Abstract excerpt

The suppression of type I interferon (IFN) signalling by the ISG15-USP18-STAT2 inhibitory complex (ISG15 IC) is an established regulatory mechanism of the antiviral response. However, a molecular understanding of how the ISG15 IC forms to suppress IFN signalling is still emerging. Here, we use AlphaFold modelling in conjunction with biochemical and biophysical approaches to elucidate the interactions of this multi...

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Identifiers and source

Literature Corpus work
446c1a6f-662d-543c-8d66-ff2a7eaef47a
DOI
10.64898/2026.03.26.714284
Open publication

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Dissecting the interactions of the ISG15-USP18-STAT2 inhibitory complexDOI 10.64898/2026.03.26.714284
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