Article

Functionally and epigenetically distinct programs define the heterogeneity of trained immunity

2026-07-13

Abstract excerpt

<title>Abstract</title> <p>Trained immunity (TRIM) describes the long-term functional reprogramming of innate immune cells after an initial encounter with a microbial or endogenous stimulus, enabling cross-protection against unrelated pathogens. This memory has been studied almost exclusively as a single, pro-inflammatory state. Nevertheless, whether qualitatively distinct TRIM programs exist remains elusive. To...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1e2dfcf-363c-5575-9fb3-26297416a7c0
DOI: 10.21203/rs.3.rs-10242517/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functionally and epigenetically distinct programs define the heterogeneity of trained immunityDOI 10.21203/rs.3.rs-10242517/v1Read

The mechanisms and cross-protection of trained innate immunitySemantic proximity Read

Innate Immune Memory is Stimulus SpecificSemantic proximity Read

Hematopoietic stem and progenitor cells as a reservoir for trained immunitySemantic proximity Read

Trained immunity: General and emerging conceptsSemantic proximity Read

RIG-I activation primes and trains innate antiviral immune memorySemantic proximity Read

Trained immunity as a novel therapeutic strategySemantic proximity Read

The causes and consequences of trained immunity in myeloid cellsSemantic proximity Read

Infection-induced trained immunity: a twist in paradigm of innate host defense and generation of immunological memorySemantic proximity Read

Trained immunity: adaptation within innate immune mechanismsSemantic proximity Read

Type-2-immune history imprints local training in nerve-airway associated interstitial macrophages (NAMs) for disease tolerance during respiratory viral infectionSemantic proximity Read

Epigenetics and Trained Immunity.Semantic proximity Read

Trained immunity: implications for vaccinationSemantic proximity Read