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The mechanisms and cross-protection of trained innate immunity

8 Dec 2022

Abstract excerpt

In recent years, the traditional cognition of immunological memory being specific to adaptive immunity has been challenged. Innate immunity can mount enhanced responsiveness upon secondary stimulation, and a phenomenon is termed trained innate immunity. Trained innate immunity is orchestrated by distinct metabolic and epigenetic reprogramming in both circulating myeloid cells and myeloid progenitor cells in bone...

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PMID: 36482472
DOI: 10.1186/s12985-022-01937-5

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