Article

A comprehensive benchmark for multiple highly efficient base editors with broad targeting scope

2024-12-20

Abstract excerpt

As the toolbox of base editors (BEs) expands, selecting appropriate BE and guide RNA (gRNA) to achieve optimal editing efficiency and outcome for a given target becomes challenging. Here, we construct a set of 10 adenine and cytosine BEs with high activity and broad targeting scope, and comprehensively evaluate their editing profiles and properties head-to-head with 34,040 BE-gRNA-target combinations using genomic...

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Literature Corpus work: c42bb054-8c12-5429-a6a1-afcaef79e3fc
DOI: 10.1101/2024.12.17.628899

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