Article

OPED: an optimal prime editing guide RNA designer based on deep learning and transfer learning

2023-01-25

Abstract excerpt

Prime editors (PEs) are promising genome editing tools, but efficiency pre-testing of prime editing guide RNA (pegRNA) design is still laborious and time-consuming due to the lack of accurate and universal approaches. Here, we design a customized attention-based model OPED and train it using transfer learning to improve the accuracy and universality of efficiency prediction and design optimal pegRNAs. We demonstra...

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Literature Corpus work: 1c74cd00-f958-539e-bc90-33d7252a23e1
DOI: 10.21203/rs.3.rs-2340162/v1

Open publication

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