Article

Predicting base editing outcomes using position-specific sequence determinants

2021-09-16

Abstract excerpt

Nucleotide-level control over DNA sequences is poised to power functional genomics studies and lead to new therapeutics. CRISPR/Cas base editors promise to achieve this ability, but the determinants of their activity remain incompletely understood. We measured base editing frequencies in two human cell lines for two cytosine and two adenine base editors at ∼14,000 target sequences. Base editing activity is sequenc...

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Identifiers and source

Literature Corpus work: 9331f54d-02d5-5b6c-b53d-079e8cbf35a1
DOI: 10.1101/2021.09.16.460622

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