Article

Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

2024-04-11

Abstract excerpt

<h4>Summary</h4> Base editors enable the direct conversion of target bases without inducing double-strand breaks, showing great potential for disease modeling and gene therapy. Yet, their applicability has been constrained by the necessity for specific protospacer adjacent motif (PAM). We generated four versions of near-PAMless base editors and systematically evaluated their editing patterns and efficiencies usin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 778576d2-a909-5736-b2b2-7dca914498f7
DOI: 10.1101/2024.04.08.588505

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editorsDOI 10.1101/2024.04.08.588505Read

A comprehensive benchmark for multiple highly efficient base editors with broad targeting scopeSemantic proximity Read

Predicting base editing outcomes using position-specific sequence determinantsSemantic proximity Read

Predicting base editing outcomes using position-specific sequence determinantsSemantic proximity Read

Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVsSemantic proximity Read

Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors.Semantic proximity Read

Predicting prime editing efficiency and product purity by deep learning.Semantic proximity Read

Sensitive, direct detection of non-coding off-target base editor unwinding and editing in primary cellsSemantic proximity Read

Engineering a precise adenine base editor with minimal bystander editing.Semantic proximity Read

<i>beditor</i> : A computational workflow for designing libraries of guide RNAs for CRISPR-mediated base editingSemantic proximity Read

OPED: an optimal prime editing guide RNA designer based on deep learning and transfer learningSemantic proximity Read

Predicting Mutations Generated by Cas9, Base Editing, and Prime Editing in Mammalian Cells.Semantic proximity Read

A-to-G/C/T and C-to-T/G/A dual-function base editor for creating multi-nucleotide variants.Semantic proximity Read