Article
Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics.
Behavior genetics - 1 Nov 2023
Williams Camille M, Poore Holly, Tanksley Peter T, Kweon Hyeokmoon, Courchesne-Krak Natasia S, Londono-Correa Diego, Mallard Travis T, Barr Peter, Koellinger Philipp D, Waldman Irwin D, Sanchez-Roige Sandra, Harden K Paige, Palmer Abraham A, Dick Danielle M, Karlsson Linnér Richard
Abstract excerpt
Proprietary genetic datasets are valuable for boosting the statistical power of genome-wide association studies (GWASs), but their use can restrict investigators from publicly sharing the resulting summary statistics. Although researchers can resort to sharing down-sampled versions that exclude restricted data, down-sampling reduces power and might change the genetic etiology of the phenotype being studied. These...
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