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Article

Monogenic and polygenic inheritance become instruments for clonal selection.

Nature - 1 Aug 2020

Loh Po-Ru, Genovese Giulio, McCarroll Steven A

Abstract excerpt

Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are commonly acquired with age and increase the risk of blood cancer1-9. The blood clones identified so far contain diverse large-scale mosaic chromosomal alterations (deletions, duplications and copy-neutral loss of heterozygosity (CN-LOH)) on all chromosomes1,2,5,6,9, but the sources of selective advantage that drive the...

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Identifiers

PMID: 32581363
DOI: 10.1038/s41586-020-2430-6
PMCID: PMC7415571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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