Article

Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α-cell cAMP

2023-07-31

Abstract excerpt

<h4>Objective</h4> Pancreatic islets are nutrient sensors that regulate organismal blood glucose homeostasis. Glucagon release from the pancreatic α-cell is important under fasted, fed, and hypoglycemic conditions, yet metabolic regulation of α-cells remains poorly understood. Here, we identified a previously unexplored role for physiological levels of leucine, which is classically regarded as a β-cell fuel, in t...

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Literature Corpus work: c3a0806d-580f-5cc0-a795-8a699226b579
DOI: 10.1101/2023.07.31.551113

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