Article

Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and Signaling

2025-03-17

Abstract excerpt

<title>Abstract</title> <p>Background and aim: Lysine is an essential amino acid with insulinotropic effects in humans. <italic>In vitro</italic>, lysine also potentiates glucose-stimulated insulin secretion (GSIS) in β cell lines and rodent pancreatic islets. For decades it has been assumed that insulinotropic action of lysine is mediated by plasma membrane depolarization similar to arginine. Aminoadipate-Semia...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6011b9d6-7447-5dbf-a1f2-694f320a665a
DOI: 10.21203/rs.3.rs-6154814/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and SignalingDOI 10.21203/rs.3.rs-6154814/v1Read

Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and SignalingSemantic proximity Read

Glutaminolysis and insulin secretion: from bedside to bench and back.Semantic proximity Read

Mechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinism.Semantic proximity Read

Comparative Enzymatic Profiling of Enteric vs. Cortical Neural Stem Cells: Establishing a Methodological Foundation for Modeling Enteric NeurodegenerationSemantic proximity Read

Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α-cell cAMPSemantic proximity Read

Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion.Semantic proximity Read

Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivitySemantic proximity Read

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.Semantic proximity Read

Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt.Semantic proximity Read

Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signalingSemantic proximity Read

Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer CellsSemantic proximity Read

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.Semantic proximity Read