Article

Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and Signaling

2025-03-03

Abstract excerpt

<h4>Background and aim</h4> Lysine is an essential amino acid with insulinotropic effects in humans. In vitro , lysine also potentiates glucose-stimulated insulin secretion (GSIS) in β cell lines and rodent pancreatic islets. For decades it has been assumed that insulinotropic action of lysine is mediated by plasma membrane depolarization similar to arginine. Aminoadipate-Semialdehyde Synthase (AASS) is a mitoch...

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Literature Corpus work: 0628ca5c-5293-5fb8-a92c-073fe75f67a5
DOI: 10.1101/2025.03.03.641187

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