Article

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

2022-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Using 13 C 6 glucose labeling coupled to GC-MS and 2D 1 H- 13 C HSQC NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β cell function. In both mouse and human islets, the contribution of glucose to the TCA cycle is similar. Pyruvate-fueling of the TCA cycle is primarily mediated by the activity of pyruvate dehydrogenase, with lower flux throug...

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Literature Corpus work: a7b7151f-717e-5a27-8f77-e21e1e1261cc
DOI: 10.1101/2022.12.21.521364

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