Article

Proinflammatory cytokine-induced alpha-cell impairment in human islet microtissues is partially restored by dual incretin receptor agonism

2024-06-27

Abstract excerpt

<h4>Aims/hypothesis</h4> In type 1 diabetes, the counterregulatory glucagon response to low plasma glucose is impaired. The resulting increased risk of hypoglycaemia necessitates novel strategies to ameliorate alpha-cell impairment. Here, we aimed to establish an in vitro model of alpha-cell impairment in type 1 diabetes using human islet microtissues (MTs) exposed to proinflammatory cytokines. Additionally, we i...

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Literature Corpus work: 454e9355-a0c1-5214-a4fd-2884d863a829
DOI: 10.1101/2024.06.26.600877

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