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Beta hydroxybutyrate alters beta cell identity and function in human islets

2025-12-26

Abstract excerpt

Fasting alters insulin secretion in humans and islet cell composition in mice. Fasting triggers ketogenesis, which increases beta hydroxybutyrate (BHB) levels. BHB is a signaling molecule that alters insulin secretion in primary islets. We hypothesized that BHB alters human islet cell composition and identity. Primary human islets were cultured with R-BHB or its non-metabolizable enantiomer, S-BHB. Human islets cu...

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Literature Corpus work
2fa290bd-c339-52f1-8e2b-ce8f448687c9
DOI
10.64898/2025.12.24.696385
Open publication

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Beta hydroxybutyrate alters beta cell identity and function in human isletsDOI 10.64898/2025.12.24.696385
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