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Article

Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control.

Molecular cell - 20 Aug 2020

Meydan Sezen, Guydosh Nicholas R

Abstract excerpt

The ribosome-associated protein quality control (RQC) system that resolves stalled translation events is activated when ribosomes collide and form disome, trisome, or higher-order complexes. However, it is unclear whether this system distinguishes collision complexes formed on defective mRNAs from those with functional roles on endogenous transcripts. Here, we performed disome and trisome footprint profiling in...

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Identifiers

PMID: 32615089
DOI: 10.1016/j.molcel.2020.06.010
PMCID: PMC7484464

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