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Article

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination.

Molecular cell - 16 Feb 2017

Juszkiewicz Szymon, Hegde Ramanujan S

Abstract excerpt

Diverse cellular stressors have been observed to trigger site-specific ubiquitination on several ribosomal proteins. However, the ubiquitin ligases, biochemical consequences, and physiologic pathways linked to these modifications are not known. Here, we show in mammalian cells that the ubiquitin ligase ZNF598 is required for ribosomes to terminally stall during translation of poly(A) sequences. ZNF598-mediated...

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Identifiers

PMID: 28065601
DOI: 10.1016/j.molcel.2016.11.039
PMCID: PMC5316413

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