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Article

A network of genetic repression and derepression specifies projection fates in the developing neocortex.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2012

Srinivasan Karpagam, Leone Dino P, Bateson Rosalie K, Dobreva Gergana, Kohwi Yoshinori, Kohwi-Shigematsu Terumi, Grosschedl Rudolf, McConnell Susan K

Abstract excerpt

Neurons within each layer in the mammalian cortex have stereotypic projections. Four genes-Fezf2, Ctip2, Tbr1, and Satb2-regulate these projection identities. These genes also interact with each other, and it is unclear how these interactions shape the final projection identity. Here we show, by generating double mutants of Fezf2, Ctip2, and Satb2, that cortical neurons deploy a complex genetic switch that uses...

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Identifiers

PMID: 23144223
DOI: 10.1073/pnas.1216793109
PMCID: PMC3511157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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