Article
Satb2 regulates callosal projection neuron identity in the developing cerebral cortex.
Neuron - 7 Feb 2008
Alcamo Elizabeth A, Chirivella Laura, Dautzenberg Marcel, Dobreva Gergana, Fariñas Isabel, Grosschedl Rudolf, McConnell Susan K
Abstract excerpt
Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ gene. In mutant mice, beta-galactosidase-labeled axons are absent from the corpus callosum and...
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