Article

Leveraging mouse chromatin data for heritability enrichment informs common disease architecture and reveals cortical layer contributions to schizophrenia

2018-09-26

Abstract excerpt

Genome-wide association studies have implicated thousands of non-coding variants across human phenotypes. However, they cannot directly inform the cellular context in which disease-associated variants act. Here, we use open chromatin profiles from discrete mouse cell populations to address this challenge. We applied stratified linkage disequilibrium score regression and evaluated heritability enrichment in 64 geno...

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Literature Corpus work: 73ed602f-d2c8-5034-b41f-dc272a46fae0
DOI: 10.1101/427484

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