Human FASTK preferentially binds single-stranded and G-rich RNA

Abstract excerpt

Fas-activated serine/threonine kinase (FASTK) is the founding member of the FASTKD protein family, which was shown to regulate the fate of mRNA molecules on multiple levels. The mitochondrial variant of FASTK co-localizes with mitochondrial RNA granules and regulates degradation of mitochondrial mRNAs, whereas the cytoplasmic and nuclear forms of FAST are involved in regulation of alternative splicing, cytoplasmic...

Topics

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• Databases, Genetic
• Gene Expression Regulation, Neoplastic
• Mitochondria
• Mutation
• Neoplasms
• RNA, Messenger
• RNA Splicing Factors
• Spliceosomes

Identifiers and source

Literature Corpus work

c393a359-fe92-5190-ab02-fbe860948cb6

DOI

10.1101/2024.07.16.603671