Article
Identification of deleterious non-synonymous single nucleotide polymorphisms in the mRNA decay activator ZFP36L2.
RNA biology - 1 Dec 2025
Akçeşme Betül, Hekimoğlu Hilal, Chirasani Venkat R, İş Şeyma, Atmaca Habibe Nur, Waldern Justin M, Ramos Silvia B V
Abstract excerpt
More than 4,000 single nucleotide polymorphisms (SNP) variants have been identified in the human ZFP36L2 gene, however only a few have been studied in the context of protein function. The tandem zinc finger domain of ZFP36L2, an RNA binding protein, is the functional domain that binds to its target mRNAs. This protein/RNA interaction triggers mRNA degradation, controlling gene expression. We identified 32...
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