Article

Nuclear PKM2 promotes pre-mRNA processing by binding folded RNA G-quadruplexes

2022-04-06

Abstract excerpt

<title>Abstract</title> <p>Nuclear localization of the pyruvate kinase M2 isoform (PKM2) is widely observed in cancer and correlates with its aggressiveness, but its contribution to gene regulation and pathogenesis remains unclear. We find that PKM2 is a non-canonical RNA binding protein that specifically recognizes RNA G-quadruplex (rG4) structures and binds precursor mRNAs (pre-mRNAs) in the nucleus of human ce...

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Literature Corpus work: 04db8151-0c1a-5ed8-97e9-cf5360b5dddf
DOI: 10.21203/rs.3.rs-1495021/v1

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