Article

Alternative splicing modulation by G-quadruplexes

2019-07-12

Abstract excerpt

Alternative splicing is central to metazoan gene regulation but the regulatory mechanisms involved are only partially understood. Here, we show that G-quadruplex (G4) motifs are enriched ~3-fold both upstream and downstream of splice junctions. Analysis of in vitro G4-seq data corroborates their formation potential. G4s display the highest enrichment at weaker splice sites, which are frequently involved in altern...

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Literature Corpus work: 743db84d-2c03-51af-a6de-8f3a53dfd42a
DOI: 10.1101/700575

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