Article

Microglial homeostasis requires balanced CSF-1/CSF-2 receptor signaling

2019-12-23

Abstract excerpt

<h4>Summary</h4> CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Previous studies in the Csf1r +/- mouse model of ALSP hypothesized a central role of elevated cerebral Csf2 expression. Here we show that monoallelic deletion of Csf2 rescues most behavioral deficits and histopathological changes in Csf1r +/- mice by preventing microgliosis and...

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Literature Corpus work: 9a4d3c02-ee0c-5042-8f07-11e53eced454
DOI: 10.1101/2019.12.23.885186

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