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Article

KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis.

Annals of the rheumatic diseases - 12 Jun 2024

Singh Manish Kumar, Rallabandi Harikrishna Reddy, Zhou Xu-Jie, Qi Yuan-Yuan, Zhao Zhan-Zheng, Gan Ting, Zhang Hong, Looger Loren L, Nath Swapan K

Abstract excerpt

OBJECTIVE: A recent genome-wide association study linked KLF2 as a novel Asian-specific locus for systemic lupus erythematosus (SLE) susceptibility. However, the underlying causal functional variant(s), cognate target gene(s) and genetic mechanisms associated with SLE risk are unknown. METHODS: We used bioinformatics to prioritise likely functional variants and validated the best candidate with diverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38373841
DOI: 10.1136/ard-2023-224953
PMCID: PMC11168881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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