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Genetic diversity, phylogroup distribution and virulence gene profile of pks positive Escherichia coli colonizing human intestinal polyps.

Microbial pathogenesis - 1 Nov 2017

Sarshar Meysam, Scribano Daniela, Marazzato Massimiliano, Ambrosi Cecilia, Aprea Maria Rita, Aleandri Marta, Pronio Annamaria, Longhi Catia, Nicoletti Mauro, Zagaglia Carlo, Palamara Anna Teresa, Conte Maria Pia

Abstract excerpt

Some Escherichia coli strains of phylogroup B2 harbor a (pks) pathogenicity island that encodes a polyketide-peptide genotoxin called colibactin. It causes DNA double-strand breaks and megalocytosis in eukaryotic cells and it may contribute to cancer development. Study of bacterial community that colonizes the adenomatous polyp lesion, defined as precancerous lesions, could be helpful to assess if such pathogenic...

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PMID: 28987619
DOI: 10.1016/j.micpath.2017.10.009

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