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Article

Evolutionary Dynamics Based on Comparative Genomics of Pathogenic Escherichia coli Lineages Harboring Polyketide Synthase (pks) Island.

mBio - 2 Mar 2021

Suresh Arya, Shaik Sabiha, Baddam Ramani, Ranjan Amit, Qumar Shamsul, Jadhav Savita, Semmler Torsten, Ghazi Irfan A, Wieler Lothar H, Ahmed Niyaz

Abstract excerpt

The genotoxin colibactin is a secondary metabolite produced by the polyketide synthase (pks) island harbored by extraintestinal pathogenic E. coli (ExPEC) and other members of the Enterobacteriaceae that has been increasingly reported to have critical implications in human health. The present study entails a high-throughput whole-genome comparison and phylogenetic analysis of such pathogenic E. coli isolates to...

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Identifiers

PMID: 33653937
DOI: 10.1128/mBio.03634-20
PMCID: PMC8545132

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