Article

Integration of human and mouse single-cell transcriptomes of the developing cerebellum nominates cells-of-origin for Group 3 and 4 medulloblastoma

2026-01-22

Abstract excerpt

The cerebellar rhombic lip neurogenic niche is critical for glutamatergic neurogenesis, and dysregulated differentiation of rhombic lip lineage cells is hypothesized to cause medulloblastoma (MB), a malignant pediatric cancer lacking targeted therapies. Humans have an expanded rhombic lip subventricular zone compartment not seen in mice or macaques, and the common Group 4 subtype of MB is hypothesized to arise by...

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Literature Corpus work: 5e566425-50c8-5934-8612-b609ed76772e
DOI: 10.64898/2026.01.22.701123

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