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Developmental Origins and Oncogenesis in Medulloblastoma

14 Feb 2025

Abstract excerpt

Medulloblastoma is the most common malignant pediatric brain cancer and is broadly categorized into four molecular subgroups. Understanding the cell origins of medulloblastoma is crucial for preventing tumor formation and relapse. Recent single-cell transcriptomics studies have identified the potential cell lineage vulnerabilities and mechanisms underpinning malignant transformation in medulloblastoma. Emerging...

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PMID: 39952636
DOI: 10.1146/annurev-neuro-112723-061540

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