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Article

Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma.

Acta neuropathologica - 1 Feb 2011

Al-Halabi Hani, Nantel Andre, Klekner Almos, Guiot Marie-Christine, Albrecht Steffen, Hauser Peter, Garami Miklos, Bognar Laszlo, Kavan Peter, Gerges Noha, Shirinian Margret, Roberge David, Muanza Thierry, Jabado Nada

Abstract excerpt

Medulloblastoma (MB) represents approximately 4% of adult brain tumours, and as such is a poorly studied disease. Although many adult MB are treated using paediatric MB protocols, the reported outcomes are inferior to those observed in children. It remains unclear whether biologic differences underlie these clinical observations. We investigated the molecular characteristics of 31 adult MB. Twelve and 19 adult MB...

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Identifiers

PMID: 21107850
DOI: 10.1007/s00401-010-0780-0

Genes

SHH
PTCH1
SFRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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