Article

CRISPR-mediated biocontainment

2020-02-04

Abstract excerpt

We have exploited the repetitive nature of transposable elements of the human genome to generate synthetic circuits. Transposable elements such as LINE-1 and Alu have successfully replicated in mammalian genomes throughout evolution to reach a copy number ranging from thousands to more than a million. Targeting these repetitive elements with programmable DNA nucleases such as CRISPR-Cas9 rapidly induce extremely h...

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Literature Corpus work: 9ae2a707-877e-5cfc-ac16-92667f0601d2
DOI: 10.1101/2020.02.03.922146

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