Article

Definition of germ layer cell lineage alternative splicing programs reveals a critical role for Quaking in specifying cardiac cell fate

2020-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Alternative splicing is critical for development; however, its role in the specification of the three embryonic germ layers is poorly understood. By performing RNA-Seq on human embryonic stem cells (hESCs) and derived definitive endoderm, cardiac mesoderm, and ectoderm cell lineages, we detect distinct alternative splicing programs associated with each lineage. The most prominent splicing progra...

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Literature Corpus work: c3148114-5520-5009-86bf-a3a7f87418ca
DOI: 10.1101/2020.12.22.423880

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