Article
RNA Splicing: Regulation and Dysregulation in the Heart.
Circulation research - 5 Feb 2016
van den Hoogenhof Maarten M G, Pinto Yigal M, Creemers Esther E
Abstract excerpt
RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example of the Darwinian function follows form concept. A mutation that leads to a new mRNA (form) that encodes for a new functional protein (function) is likely to be retained, and this way, the genome has gradually evolved to encode for...
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