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Article

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function

4 Jan 2021

Abstract excerpt

Abstract The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders.Qkiis found highly expressed in developing and adult hearts. By employing the human embryonic stem cell (hESC) to cardiomyocyte differentiation system and generating QKI-deficient hESCs (hESCs-QKIdel) using...

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PMID: 33397958
DOI: 10.1038/s41467-020-20327-5

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