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Alpha-Synuclein Dysregulation in Systemic Pathophysiology of Synucleinopathies

7 Jul 2025

Abstract excerpt

Alpha-synuclein (α-syn) has long been identified as the etiologic agent of multiple neurodegenerative diseases, the most common and well-known of which are Parkinson's disease (PD) and Lewy body dementia (LBD). While it is known that the pathophysiology of these synucleinopathies involves aggregation of improperly-folded α-syn, the mechanisms leading to its accumulation have not been fully identified. However,...

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PMID: 40765334
DOI: 10.31083/fbl27178

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