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Article

Alpha-synuclein: from secretion to dysfunction and death

19 Jul 2012

Abstract excerpt

The aggregation, deposition, and dysfunction of alpha-synuclein (aSyn) are common events in neurodegenerative disorders known as synucleinopathies. These include Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. A growing body of knowledge on the biology of aSyn is emerging and enabling novel hypotheses to be tested. In particular, the hypothesis that aSyn is secreted from neurons, thus...

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PMID: 22825468
DOI: 10.1038/cddis.2012.94

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