Article

Global Geo-Pharmacogenomics: Environmental Mutational Signatures Drive Population-Level Heterogeneity in Anticancer Drug Response

2026-04-10

Abstract excerpt

The interplay between the environmental exposome and the cancer genome remains a critical "blind spot" in precision oncology. While somatic mutational signatures genomic fossils imprinted by exposures such as ultraviolet radiation, tobacco smoke, and industrial pollutants are well characterized for their etiological significance, their functional impact on therapeutic efficacy remains largely unexplored. We hypoth...

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Literature Corpus work: c2cbce9a-e904-5c32-a0fc-10296816e6d0
DOI: 10.20944/preprints202604.0686.v1

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