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Implementing Mutational Epidemiology on a Global Scale: Lessons from Mutographs.

Cancer discovery - 13 Jan 2025

Stratton Michael R, Humphreys Laura, Alexandrov Ludmil B, Balmain Allan, Brennan Paul, Campbell Peter J, Phillips David H

Abstract excerpt

The Mutographs Cancer Grand Challenge team aimed to discover unknown causes of cancer through mutational epidemiology, an alliance of cancer epidemiology and somatic genomics. By generating whole-genome sequences from thousands of cancers and normal tissues from more than 30 countries on five continents, it discovered unsuspected mutagenic exposures affecting millions of people, raised the possibility that some...

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Identifiers

PMID: 39801236
DOI: 10.1158/2159-8290.CD-24-1687
PMCID: PMC13539406

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