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Article

Navigating luminal heterogeneity: etiology-based proteogenomic subtyping for targeted treatment strategies in breast cancer.

Molecular cancer - 3 Jun 2026

Chang Ya-Hsuan, Chen Yi-Ju, Hong Zhi-Jie, Hsiao Yi-Jing, Lin Kuen-Tyng, Liao Guo-Shiou, Su Sheng-Fang, Lin Ze-Shiang, Chen Huei-Wen, Han Chia-Li, Chen Eric Sheng-Wen, Hsu Yin-Chen, Chen Yan-Ming, Fang Hao, Yang Hao-Chin, Chen Yan-Si, Lin Chien-Yu, Hsu Hsiang-En, Lin Ching-Hung, Jiang Pin-Lian, Wu Pei-Shan, Chen Ching-Wen, Hung Chen-Ting, Wu Ethan, Chiu Wei-Tzu, Hsing Fan-Ni, Liu Tsai-Pei, Wang Chia-Yu, Wang Yu-Tai, Yeh Chang-Wei, Liao Ki-Hok, Robles Ana I, Rodriguez Henry, Yang Show-Ling, Hung Mien-Chie, Lu Yen-Shen, Chen Hsuan-Yu, Yu Sung-Liang, Yu Jyh-Cherng, Chen Yu-Ju

Abstract excerpt

BACKGROUND: Luminal breast cancer is rising rapidly among East Asian women, particularly younger patients, with variable clinical outcome, yet current risk-stratification models inadequately predict early recurrence of under-studied young-onset cases. We hypothesize that the interplay between endogenous mutagenic processes and overlooked environmental carcinogen exposure drives molecular diversity, revealing...

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Identifiers

PMID: 42237381
DOI: 10.1186/s12943-026-02701-x
PMCID: PMC13459638

Genes

CDK4
ALDH1L2
APOBEC3B
ARF4
CDK9
HDAC2
POLR2A
SCAMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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