Article
The Mutational Landscape of Cancer's Vulnerability to Ionizing Radiation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2022
Gopal Priyanka, Yard Brian D, Petty Aaron, Lal Jessica C, Bera Titas K, Hoang Trung Q, Buhimschi Alexandru D, Abazeed Mohamed E
Abstract excerpt
PURPOSE: Large-scale sequencing efforts have established that cancer-associated genetic alterations are highly diverse, posing a challenge to the identification of variants that regulate complex phenotypes like radiation sensitivity. The impact of the vast majority of rare or common genetic variants on the sensitivity of cancers to radiotherapy remains largely unknown. EXPERIMENTAL DESIGN: We developed a scalable...
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