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A Novel Feeder cell based on 4-1BBL and Membrane-bound IL-21/ IL-15 Induce Highly Expansion and Anti-tumor Effect of Natural Killer Cells

2024-08-09

Abstract excerpt

<title>Abstract</title> <p>Background Natural killer (NK) cell immunotherapy is a promising approach for cancer treatment. However, its extensive clinical application was limited to the large-scale clinical-grade expansion of NK cells. In this study, we expanded NK cells from healthy donor’s peripheral blood mononuclear cells (PBMCs) using a newly designed K562 feeder cell line. Methods The feeder cells were ge...

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Literature Corpus work: c2bb3ea8-8ed9-51f7-bb68-20f8b7b47677
DOI: 10.21203/rs.3.rs-4741998/v1

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