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Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing

11 Feb 2022

Abstract excerpt

Genome engineered natural killer (NK) cell therapies are emerging as a promising cancer immunotherapy platform with potential advantages and remaining uncertainties. Feeder cells induce activation and proliferation of NK cells via cell surface receptor-ligand interactions, supported by cytokines. Feeder cell expanded NK cell products have supported several NK cell adoptive transfer clinical trials over the past...

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PMID: 35222382
DOI: 10.3389/fimmu.2022.802906

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