Article

Overcoming the UCB HSCs –Derived NK Cells Dysfunctionality through Harnessing RAS/MAPK, IGF-1R and TGF-β Signaling Pathways

2020-11-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Natural killer (NK) cells differentiated from umbilical cord blood (UCB) hematopoietic stem cells (HSCs) may be more suitable for cell-based immunotherapy compared to NK cells from adult donors. This is due to opportunity to choose alloreactive donors and potentially more robust <italic>in vivo</italic> expansion. However, the cytotoxicity of UCB-HSC derived NK ce...

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Literature Corpus work: 71d228dc-2f76-5f92-aa51-edbb485a90ac
DOI: 10.21203/rs.3.rs-98506/v1

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