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Phenotypic and functional characterisation of locally produced natural killer cells ex vivo expanded with the K562-41BBL-mbIL21 cell line.

Clinical and experimental medicine - 1 Oct 2023

Shman Tatsiana V, Vashkevich Katsiaryna P, Migas Alexandr A, Matveyenka Mikhail A, Lasiukov Yauheni A, Mukhametshyna Nastassia S, Horbach Katsiaryna I, Aleinikova Olga V

Abstract excerpt

We characterised the expansion, phenotype and functional activity of natural killer (NK) cells obtained for a clinical trial. Nineteen expansion procedures were performed to obtain NK cell products for 16 patients. NK cells were expanded ex vivo from haploidentical donor peripheral blood mononuclear cells in the presence of the locally generated feeder cell line K-562 with ectopic expression of 4-1BBL and...

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PMID: 36527513
DOI: 10.1007/s10238-022-00974-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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