Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK cells with Enhanced Antitumor Activity.

Cells - 27 Mar 2020

Oberoi Pranav, Kamenjarin Kathrina, Ossa Jose Francisco Villena, Uherek Barbara, Bönig Halvard, Wels Winfried S

Abstract excerpt

Obtaining sufficient numbers of functional natural killer (NK) cells is crucial for the success of NK-cell-based adoptive immunotherapies. While expansion from peripheral blood (PB) is the current method of choice, ex vivo generation of NK cells from hematopoietic stem and progenitor cells (HSCs) may constitute an attractive alternative. Thereby, HSCs mobilized into peripheral blood (PB-CD34+) represent a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34
Share to Cell Death

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Mobilization

Share to Hematopoietic Stem Cells

Share to Interleukin-21

Share to Interleukins

Share to Killer Cells, Natural

Share to Tissue Donors

Source

Open in PubMed Open full text

Identifiers

PMID: 32230942
DOI: 10.3390/cells9040811
PMCID: PMC7226771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK cells with Enhanced Antitumor Activity.PMID 32230942Read ↗

A Novel Feeder cell based on 4-1BBL and Membrane-bound IL-21/ IL-15 Induce Highly Expansion and Anti-tumor Effect of Natural Killer CellsSemantic proximity Read ↗

Improving the Outcome of Leukemia by Natural Killer Cell-Based Immunotherapeutic StrategiesSemantic proximity Read ↗

Overcoming the UCB HSCs –Derived NK Cells Dysfunctionality through Harnessing RAS/MAPK, IGF-1R and TGF-β Signaling PathwaysSemantic proximity Read ↗

In-vitro Expansion and Transduction of Primary Natural Killer Cells Using Feeder Cells Co-expressing Co-stimulatory Receptors and Membrane-bound IL-21Semantic proximity Read ↗

Ex vivo generated natural killer cells acquire typical natural killer receptors and display a cytotoxic gene expression profile similar to peripheral blood natural killer cells.Semantic proximity Read ↗

High-Risk Leukemia: Past, Present, and Future Role of NK CellsSemantic proximity Read ↗

A Novel Natural Killer Cell Expansion Technology for the Development of Cellular ImmunotherapiesSemantic proximity Read ↗

Dark NKnight rising: a current perspective on NK cell and CAR-NK cell therapySemantic proximity Read ↗

Comparative analysis of iPSC-derived NK cells from two differentiation strategies reveals distinct signatures and cytotoxic activitiesSemantic proximity Read ↗

An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells.Semantic proximity Read ↗

Natural killer cell therapy for hematologic malignancies: successes, challenges, and the futureSemantic proximity Read ↗

Phenotypic and functional characterisation of locally produced natural killer cells ex vivo expanded with the K562-41BBL-mbIL21 cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.