Article

Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance

2024-10-31

Abstract excerpt

<h4>SUMMARY</h4> Effective cancer immunotherapies restore anti-tumor immunity by rewiring cell-cell communication. Treatment-induced changes in communication can be inferred from single-cell RNA-sequencing (scRNA-seq) data, but current methods do not effectively manage heterogeneity within cell types. Here we developed a computational approach to efficiently analyze scRNA-seq-derived, single-cell-resolved cell-ce...

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Literature Corpus work: 6ac3708d-44c3-565f-a163-38cbb313ba30
DOI: 10.1101/2024.10.28.620093

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