Article

Lung tumor-infiltrating T <sub>reg</sub> have divergent transcriptional profiles and function linked to checkpoint blockade response

2022-12-15

Abstract excerpt

Regulatory T cells (T reg ) are conventionally viewed to suppress endogenous and therapyinduced anti-tumor immunity; however, their role in modulating responses to immune checkpoint blockade (ICB) is unclear. In this study, we integrated single-cell RNAseq/TCRseq of >73,000 tumor-infiltrating T reg (TIL-T reg ) from anti-PD-1-treated and treatment naive non-small cell lung cancers (NSCLC) with single cell analy...

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Literature Corpus work: 27cdf5b6-53b1-5426-85e9-323527d7ffc3
DOI: 10.1101/2022.12.13.520329

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