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Systematic identification and targeting of master regulator checkpoints (MRC) governing tumor microenvironment-mediated immune evasion

1 Jun 2025

Abstract excerpt

Abrogating the immunoevasive role of the tumor immune microenvironment (TIME) represents a critical yet still elusive challenge in cancer treatment. Progress in this area has been hampered by both technological limitations and incomplete understanding of TIME-dependent immunoevasion mechanisms. We hypothesize that the immune-evasive role of TIME subpopulations-including regulatory T cells, cancer-associated...

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PMID: 40555564
DOI: 10.1136/jitc-2024-011355

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